解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11040322
更新日期:2019-04-03 00:00:00
abstract::Bombyx mori bidensovirus (BmBDV) is a single-stranded DNA (ssDNA) virus from the genus Bidensovirus of the Bidnaviridae family, which, thus far, solely infects insects. It has a unique genome that contains bipartite DNA molecules (VD1 and VD2). In this study, we explored the detailed transcription mapping of the compl...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11040325
更新日期:2019-04-03 00:00:00
abstract::Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11030300
更新日期:2019-03-26 00:00:00
abstract::Lassa virus (LASV) and Mopeia virus (MOPV) are two closely related Old-World mammarenaviruses. LASV causes severe hemorrhagic fever with high mortality in humans, whereas no case of MOPV infection has been reported. Comparing MOPV and LASV is a powerful strategy to unravel pathogenic mechanisms that occur during the c...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030293
更新日期:2019-03-23 00:00:00
abstract::Significantly higher numbers of human infections with H5N1 virus have occurred in Indonesia and Egypt, compared with other affected areas, and it is speculated that there are specific viral factors for human infection with avian H5N1 viruses in these locations. We previously showed PB2-K526R is present in 80% of Indon...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030292
更新日期:2019-03-22 00:00:00
abstract::Infectious bronchitis virus (IBV) and Newcastle disease virus (NDV) are two poultry pathogens seriously affecting the poultry industry. Here, IBV S1 and the ectodomain of NDV F proteins were separately linked with the trans-membrane and carboxy-terminal domain of IBV S protein (STMCT), composing rS and rF; thus, a nov...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030254
更新日期:2019-03-13 00:00:00
abstract::The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is widely explored for sequence-specific attack on HIV-1 proviral DNA. We recently identified dual-guide RNA (dual-gRNA) combinations that can block HIV-1 replication permanently in infected cell cultures and prevent viral escape. Altho...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030255
更新日期:2019-03-13 00:00:00
abstract::Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11030244
更新日期:2019-03-12 00:00:00
abstract::Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030250
更新日期:2019-03-12 00:00:00
abstract::Recently, Alves-Freitas and colleagues [...]. ...
journal_title:Viruses
pub_type: 评论,信件
doi:10.3390/v11030230
更新日期:2019-03-07 00:00:00
abstract::Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely mediated by the presence or absence of human histo-blood group a...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11030226
更新日期:2019-03-06 00:00:00
abstract::Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030222
更新日期:2019-03-05 00:00:00
abstract::Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to stu...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030211
更新日期:2019-03-02 00:00:00
abstract:BACKGROUND:Duck plague virus (DPV) can induce apoptosis in duck embryo fibroblasts (DEFs) and in infected ducks, but the molecular mechanism of DPV-induced apoptosis remains unknown. METHODS:We first used qRT-PCR and a Caspase-Glo assay to determine whether the caspase protein family plays an important role in DPV-ind...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020196
更新日期:2019-02-24 00:00:00
abstract::Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11020185
更新日期:2019-02-21 00:00:00
abstract::Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs may cause pandemic outbreaks and zoonotic infections with, for example, highly pathogenic avian influenza virus (HPAIV) of the H5N1 and H7N9 ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11020171
更新日期:2019-02-20 00:00:00
abstract::The complete sequence and genome organization of a novel Endornavirus from the hypovirulent strain GD-2 of Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight, were identified using a deep sequencing approach and it was tentatively named as Rhizoctonia solani endornavirus 1 (RsEV1). It was composed of o...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020178
更新日期:2019-02-20 00:00:00
abstract::Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV), an infectious coronavirus first reported in 2012, has a mortality rate greater than 35%. Therapeutic antibodies are key tools for preventing and treating MERS-CoV infection, but to date no such agents have been approved for treatment of this virus. Nanobo...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020166
更新日期:2019-02-19 00:00:00
abstract::RNA virus invasion induces a cytosolic RIG-I-like receptor (RLR) signaling pathway by promoting assembly of the Mitochondrial antiviral-signaling protein (MAVS) signalosome and triggers the rapid production of type I interferons (IFNs) and proinflammatory cytokines. During this process, the pivotal kinase TANK binding...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020158
更新日期:2019-02-15 00:00:00
abstract::Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020152
更新日期:2019-02-13 00:00:00
abstract::Antigen-specific T lymphocytes play a critical role in controlling viral infections. However, we report here that preexisting virus-specific T cell responses also contribute to promoting adenovirus (Ad) infection. Previously, we found that CD14+ monocytes from Ad-seropositive individuals exhibited an increased suscept...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020154
更新日期:2019-02-13 00:00:00
abstract::Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized in vitro and in vivo infection models h...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11020151
更新日期:2019-02-12 00:00:00
abstract::Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases in affected hosts. A new genotype of feline morbillivirus, tentatively named feline morbillivirus genotype 2 (FeMV-GT2), was isolated from urine of cats with urinary tract diseases. Whole genome sequencing showed abou...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020146
更新日期:2019-02-09 00:00:00
abstract::Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAd...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020129
更新日期:2019-01-31 00:00:00
abstract::Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic replication cycle [...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v11020113
更新日期:2019-01-29 00:00:00
abstract::Fowl adenovirus serotype 4 (FAdV-4) causes hepatitis-hydropericardium syndrome (HHS), leading to severe economic losses in the poultry industry. Although the pathogenesis of FAdV-4 infection has caused much attention, the underlying molecular mechanisms remain poorly understood. Here, we identified chaperonin containi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020107
更新日期:2019-01-27 00:00:00
abstract::Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020094
更新日期:2019-01-24 00:00:00
abstract::Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020092
更新日期:2019-01-22 00:00:00
abstract::A lytic bacteriophage PHB01 specific for Pasteurella multocida type D was isolated from the sewage water collected from a pig farm. This phage had the typical morphology of the family Podoviridae, order Caudovirales, presenting an isometric polyhedral head and a short noncontractile tail. PHB01 was able to infect most...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010086
更新日期:2019-01-21 00:00:00
abstract::Three dsRNAs, in sizes of approximately 2.5⁻5 kbp, were detected in the plant pathogenic fungus Nigrospora oryzae strain CS-7.5-4. Genomic analysis showed that the 5.0 kb dsRNA was a victorivirus named as Nigrospora oryzae victorivirus 2 (NoRV2). The genome of NoRV2 was 5166 bp in length containing two overlapping ope...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010083
更新日期:2019-01-19 00:00:00
abstract::Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010076
更新日期:2019-01-18 00:00:00
abstract::Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress toward...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010074
更新日期:2019-01-17 00:00:00
abstract::Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically challenging to ascertain their nucleotide sequence using conventional se...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010070
更新日期:2019-01-16 00:00:00
abstract::Simian hemorrhagic fever virus (SHFV) causes a fulminant and typically lethal viral hemorrhagic fever (VHF) in macaques (Cercopithecinae: Macaca spp.) but causes subclinical infections in patas monkeys (Cercopithecinae: Erythrocebus patas). This difference in disease course offers a unique opportunity to compare host ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010067
更新日期:2019-01-15 00:00:00
abstract::Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of s...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010049
更新日期:2019-01-11 00:00:00
abstract::Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we have shown that bLf, and in particular its C-lobe, interacts with influenza A virus hemagglutinin and prevents infection by different ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010051
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of vi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010042
更新日期:2019-01-09 00:00:00
abstract::Despite significant improvements in therapy, the HIV/AIDS pandemic remains an important threat to public health. Current treatments fail to eradicate HIV as proviral DNA persists in long-living cellular reservoirs, leading to viral rebound whenever treatment is discontinued. Hence, a better understanding of viral rese...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11010012
更新日期:2018-12-26 00:00:00
abstract::Streptococcus thermophilus is considered one of the most important species for the dairy industry. Due to their diffusion in dairy environments, bacteriophages can represent a threat to this widely used bacterial species. Despite the presence of a CRISPR-Cas system in the S. thermophilus genome, some lysogenic strains...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010007
更新日期:2018-12-22 00:00:00
abstract::Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120729
更新日期:2018-12-19 00:00:00